Leicester have more pressing matters to deal with - hiring a new manager and battling against relegation to League One. The 2021 FA Cup winners could do without a run to clutter their calendar at this stage of the season.

That will give Southampton an advantage, to go along with the psychological one they gained by coming from 3-0 down to beat the Foxes 4-3 in midweek.

Score Prediction: Southampton 2-1 Leicester

Unai Emery is yet to win a trophy at Aston Villa despite improving them massively since replacing Steven Gerrard at the helm. Champions League qualification opportunities are more important than Europa League qualification ones though, and Villa have two chances to seal a place at Europe's top table via their Premier League position and place in the Europa League knockouts. Therefore, I don't expect him to go full strength and manage player loads instead.

Score Prediction: Aston Villa 0-1 Newcastle

Brighton have only won one of their last 13 in the Premier League, and even that came against Burnley.

They're out-of-sorts, have blanked in their last two and haven't scored more than once in any of their last six in the league.

An FA Cup run would make Liverpool less reliant on the Champions League to salvage something from a disappointing season so far; they should take it seriously.

Score Prediction: Liverpool 3-0 Brighton

This should be an absolute corker. An upwardly mobile Championship side host a vulnerable top-flight one, who're even more vulnerable in the cup due to their league position.

Blues' US owners can get some limelight with an upset here and have the quality in their squad to compete with Daniel Farke's Leeds.

Score Prediction: Birmingham 2-2 Leeds

Rob Edwards has improved Wolves; it would've been hard to make them worse, but the point stands.

Grimsby knocked Man Utd out of the Carabao Cup earlier in the season and are in the League Two play-off mix.

Wolves should have too much quality, and it's realistically all they have left to play for - sitting 18 points from safety with 12 to go in the league.

Score Prediction: Grimbsy 2-3 Wolves

Managerless Wigan are in a League One relegation battle. Arsenal's improved squad depth this season should see them breeze past the Latics.

Mikel Arteta can afford to rotate and still cruise past their low-on-confidence visitors.

Score Prediction: Arsenal 4-0 Wigan