Mainz were able to snatch a point against Stuttgart in their last league outing, as Danny Da Costa scored in the 91st minute to level the scores at 2-2.
Mainz have now failed to win any of their last four matches, and they are 14th in the Bundesliga, just two points off the relegation spots. The German side have been much more convincing in the Conference League, and they come into this round of 16 clash as heavy favourites, but their defensive issues are hard to ignore.
Sigma Olomouc will want to try and take a positive result to the second leg in Germany, so they should be attack-minded. BTTS has landed in seven of their eight Conference League matches this campaign, including both playoff games against Lausanne.
Sigma Olomouc can be effective going forward, but Mainz should be able to take advantage of their defensive structure.