While Fiorentina enter the second leg with a one-goal deficit and historical struggles against Spanish teams (W2, D4, L9), the circumstances surrounding this clash point toward their potential to mount a comeback. 

Home advantage is key here. Both of Fiorentina’s victories over Spanish opposition have come in Florence, and they are currently unbeaten in their last seven home matches (W5, D2), with just four losses in 25 all season, underscoring a growing fortress-like presence at the Stadio Artemio Franchi.

What truly sets Fiorentina apart in this scenario is their impeccable record in the UEFA Conference League’s two-legged ties — they have progressed from all 12 they’ve contested, including a notable turnaround against Panathinaikos in the last 16 after losing the first leg away. This consistency under pressure speaks to their experience, tactical maturity, and psychological resilience in European competition.

Although Real Betis are in excellent form and boast an unbeaten run of eight away games (W6, D2), the mental pressure of protecting a lead in hostile territory, combined with Fiorentina’s desperation to keep their European hopes alive for next season, creates a combustible atmosphere. Betis’ habit of scoring first may test Fiorentina early, but La Viola has shown they can respond. Six straight Conference League games with both teams scoring show they can both absorb and retaliate.

Ultimately, Fiorentina's combination of home strength, tactical experience in knockout football, and a proven ability to overturn first-leg deficits makes them a legitimate candidate to qualify, especially in front of a passionate home crowd in what could be a defining night of their season.

A BTTS bet stands out as one of the most statistically supported picks heading into the second leg between Fiorentina and Real Betis. The numbers from both sides paint a clear picture of defensive frailties mixed with consistent attacking output, making goals at both ends not just likely, but expected.

Fiorentina have found the net in 22 of their 25 home matches this season, underlining their ability to break teams down in Florence. However, their European outings show vulnerability at the back, with both teams scoring in each of their last six Conference League fixtures, including their last two at home. This trend highlights their habit of conceding while still being capable of responding or leading offensively.

Betis, on the other hand, bring a similar dynamic. They’ve scored first in 11 of their last 12 Conference League games, yet that early edge hasn’t translated into shutouts. In fact, BTTS has landed in each of their last six games across all competitions. The same goes for their away form, where all their last five road matches have seen both teams score, reflecting a team that pushes forward but often leaves space at the back.

Even if Betis approach cautiously with a one-goal advantage, Fiorentina’s attacking threat at home may force the visitors to react. With Betis scoring in 15 of their last 16 away games across all competitions, it’s difficult to see them staying quiet for 90 minutes, particularly if they need to respond.

In a game loaded with attacking intent and defensive fragility on both sides, BTTS is the most balanced and statistically supported selection.

Mandragora continues to be a consistent shooting threat from midfield. Averaging 1.71 shots per 90 in domestic action, the second-highest among Fiorentina’s regular starters, his output increases in Europe to 1.87 shots per 90.

He’s hit 2+ shots in seven of his last eight and ten of his last 12 appearances overall, including four of his last five in European competition. Expect him to be actively involved as Fiorentina look to overturn their first-leg deficit.

While not always a starter domestically, Bakambu thrives in European fixtures. Averaging 1.68 shots on target per 90, he’s landed at least one in each of his last four European appearances, as well as 8 consecutive starts in the competition.

He also registered one in the first leg and is in contention for the Conference League Golden Boot, having scored seven goals in his last eight appearances in the competition.