Napoli return to Serie A action looking to reassert domestic control after their midweek European triumph, as Rasmus Højlund’s brace secured a 2-1 victory over Sporting CP.

That result swiftly put to bed the disappointment of last weekend’s narrow loss to Milan (their first league defeat in 16 outings) and underlined their credentials on both fronts.

Genoa arrive in stark contrast, still searching for a first league win of the campaign and reeling from a 3-0 defeat to Lazio. With Naples a notoriously unforgiving venue and Genoa winless here in 15 attempts, this encounter promises to be a stern test.

These Napoli v Genoa Betting Stats dig further into the data ahead of kick-off.

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📈 Napoli v Genoa Form & Tactics

Napoli arrive with renewed confidence after overturning Sporting CP 2-1 in midweek, with Højlund’s brace restoring momentum after their narrow league loss at Milan. That defeat remains their only blemish of the campaign, breaking a 16-game unbeaten Serie A streak (W11, D5).

In domestic terms, their record is still imposing with four wins, one draw, and a joint-second league-leading attack that has scored in every fixture. On home soil they remain a formidable force, unbeaten since December (W11, D3) across all competitions, along with seven wins from their last eight league outings at the Stadio Diego Armando Maradona.

Genoa’s story has been far bleaker. A 3-0 collapse against Lazio last weekend confirmed their third defeat in four matches (D1), marking their lowest five-round points return (two) in three decades. Their attack has struggled to sustain pressure across 90 minutes, while defensively they have shipped seven goals in their last four league outings.

Even their more resilient away record (W1, D2 across their last four) offers little solace here, given the historical gulf. Genoa have managed just one victory in their last 24 league meetings with Napoli (D8, L15) and are winless in Naples since 2009, spanning 15 trips (D6, L9).

📔 Napoli v Genoa Formation & Team News

Napoli are expected to maintain their fluid 4-1-4-1 structure, capable of shifting into a 4-3-3. Højlund should spearhead the attack, flanked by Politano and McTominay, with De Bruyne providing creativity and progression through midfield and with Lobotka and Anguissa also anchoring transitions.

Their tactical brief will be familiar: dominate possession, circulate quickly through midfield, and overload wide areas to isolate Genoa’s full backs.

Wilson’s Genoa are likely to set up in a cautious 4-2-3-1, with Malinovsky carrying the creative burden behind lone forward Colombo. Key injuries remain disruptive with the likes of Junior Messias out and Stanciu a doubt, which will likely leave rotation in midfield, albeit with limited choice.

This could well prove telling against Napoli’s high press and aggressive territorial control. Genoa will attempt to compact centrally, block Napoli’s vertical lanes and hit on the counter, but sustained resistance over 90 minutes has been their undoing in recent weeks.

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* All odds displayed correct at the time of publishing.